Energy-dependent protein folding: modeling how a protein folding machine may work [version 1; peer review: 1 approved, 2 approved with reservations]

Background: Proteins fold robustly and reproducibly in vivo, but many cannot fold in vitro in isolation from cellular components.Despite the remarkable progress that has been achieved by the artificial intelligence approaches in predicting the protein native conformations, the pathways that lead to such conformations, either in vitro or in vivo, re

read more

An evidence base to optimise methods for involving patient and public contributors in clinical trials: a mixed-methods study

Background: In comparison with other study designs, randomised trials are regarded as particularly likely to benefit from patient and public involvement (PPI).Using mixed-methods research we investigated PPI from the perspectives of researchers and PPI contributors.Methods: Randomised trials in receipt of funding from the Health Technology Assessme

read more